Sunday December 28, 2025 Afternoon Hot Betting Markets

Submitted by Don Shapiro on

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Don Shapiro

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Football

These are the top betting markets for Sunday December 28, 2025 for the afternoon look ahead. 

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Eagles vs. Bills 

The Eagles have won three straight against the Bills in a matchup of playoff-bound teams Sunday afternoon. 

Buffalo comes into this game as a -2.5 home favorite with balanced action reported at most sportsbooks and Pay Per Head sites. 

A win over the Bills would match the Eagles’ longest streak in the series after a 4-0 run spanning 1981-87. 

In their most recent meeting, Philadelphia rallied from a 24-14 third-quarter deficit, with Elliott tying the game at 31 with a 59-yard field goal with 20 seconds remaining. After Buffalo opened overtime with a field goal, Jalen Hurts secured the win with a 12-yard touchdown run.

The Eagles became the NFC East’s first team to win consecutive division titles since Philadelphia’s four-year run from 2001-04. 

Philadelphia has a 5-3 road record. The five road wins currently match the fewest during coach Nick Sirianni’s five-year tenure, after the team went 5-4 in 2023.

The Bills set a franchise record by clinching their seventh straight playoff berth, and eighth in nine seasons under McDermott. Buffalo is also one of just five NFL teams to have won at least 11 games over six consecutive seasons.

The Bills are 25-4 in regular-season games played in December and January since 2020.

The Eagles have already clinched a playoff spot and the NFC East title.   Their main goals in Week 17 are seeding and positioning.

The Bills have already clinched a playoff berth.   However, they are still alive in the AFC East title race — they’re behind the Patriots and need wins plus help to take the division.

Bears vs. 49ers 

While both the Chicago Bears and San Francisco 49ers (each 11-4) are already in the 2025 NFL playoffs, there is still something to play for here.

A win greatly improves either team’s chances of landing the No. 1 seed in the NFC.

This is also a Sunday Night Football game with just shy of a million in trading volume at various prediction markets as of late morning. 

  • Don Shapiro, Gambling911.com 
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