2025-2026 College Football Playoff Champion Favorite Coming Into Week 6

Penn State lasted all of one week as the CFP favorite. 

James Franklin and the Nittany Lions lost yet again to another Top 10 team, and now they've flipped positions with their Big Ten brethren, Ohio State.

Oregon remains in the second spot after that victory over Penn State, and Georgia slips from fourth to seventh following its loss to Alabama. 

As we head into Week 6 of the 2025 college football season, we have a fresh favorite in the CFP Championship odds.

Penn State was second on the board last week, but the Nittany Lions have moved past rival Ohio State (who slipped into a tie for fourth) and ahead of Texas and Oregon, which are tied for second. 

The Ducks’ Dante Moore has moved into the top spot for the Heisman Trophy.

Trinidad Chambliss made the biggest jump in the Heisman odds, going from 50/1 to 12/1.

Here are notes on the odds changes after Week 5: 

CFP 

• Penn State from 6/1 to 8/1 

• Ohio State from 7/1 to 5/1 

• Alabama from 12/1 to 17/2 (+850) 

• Georgia from 7/1 to 9/1 

• Ole Miss from 28/1 to 20/1 

• LSU from 12/1 to 25/1 

• Notre Dame from 33/1 to 25/1 

Heisman 

• Dante Moore is the new favorite, going from 12/1 to 13/2 (+650) 

• John Mateer is OTB after injury 

• Ty Simpson from 25/1 to 15/2 (+750) 

• Diego Paivia from 6/1 to 20/1 

• Fernando Mendoza from 15/2 to 14/1 

• Jeremiah Smith from 14/1 to 91 

• Trinidad Chambliss from 50/1 to 12/1