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The Penn State vs. Iowa game features a line of Nittany Lions -4 after opening at -3.5.
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Sean Clifford threw for 264 yards with three touchdowns and ran for another score as No. 12 Penn State routed Purdue 35-7 on Saturday.
“Defensively we're doing some special things right now," Penn State coach James Franklin said. "We're playing championship level defense right now, and we've been doing it for a number of weeks."
Penn State pays $6000 for every $100 bet should they win the College Football Championship in 2020.
They will face off against a Hawkeyes team that had their first loss last week to Michigan.
Zach Charbonnet ran for a 2-yard touchdown to give No. 19 Michigan an early double-digit lead and its defense did the rest against No. 14 Iowa, forcing four turnovers and tallying eight sacks in a 10-3 win Saturday.
- Dan Shapiro, Gambling911.com
