Indians vs. White Sox Betting Pick, DFS Plays – April 22

Submitted by C Costigan on

Written by :

C Costigan

Published on :

Gambling911.com has your daily fantasy Baseball hot hitters for April 22.

Best Bets – Cleveland -118

Best DFS Picks – Corey Kluber

PITCHING MATCHUP: Indians RH Corey Kluber (0-1, 2.49 ERA) vs. White Sox RH Jeff Samardzija (0-1, 4.29)

Betting Line – Chicago +108, Cleveland -118, Total 7.5

Melky Cabrera (White Sox) – He’s 3-for-7 against Cleveland’s Corey Kluber. 

Jose Abreu (White Sox) – He’s 6-for-17 against Kluber with one home run.

Kluber has allowed just two runs in each of his first three starts.  He is 4-2 career record against the White Sox with one complete game and a 3.09 ERA in 10 games - nine starts.  Aside from Cabrera and Abreu, the Chicago roster is mostly off limits to  daily fantasy players.  Kluber is a decent pick as starting pitcher on the Cleveland side but this will be Samardzija’s first start against the Indians.

Cleveland is 7-3 in the last ten head-to-heads of this series. 

Chicago is 6-13 in their last 19 overall and 3-12 in their last 15 games as an underdog.

The Indians are 20-8 in Kluber’s last 28 starts vs. a team with a losing record and 15-6 in his last 21 starts with 4 days of rest.

- Dan Shapiro, Gambling911.com

Related Content

Pope Leo XIV Chicago White Sox Prop Bets: Will He Attend a Game, Mentions, More

Pope Leo XIV Chicago White Sox Prop Bets: Will He Attend a Game, Mentions, More

The Pope pays out $300 for every $100 bet should he attend one of the White Sox games.
MLB Division Series and Game 1 Odds 2026

MLB Division Series and Game 1 Odds 2026

Three of the four Wild Card series wrapped up in two games, while the Braves and Phillies will play their rubber match this evening to see which team advances to the NLDS.
Seattle Mariners Next Manager Torey Lovullo Odds

Seattle Mariners Next Manager Torey Lovullo Odds

Lovullo promises a payout of $300 for every $100 bet.
Wild Card Series, Game 1 Lines and Updated World Series Odds 2026

Wild Card Series, Game 1 Lines and Updated World Series Odds 2026

It came down to the final day of the regular season for one team, but we now have the full Wild Card postseason picture on our plates.