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It’s a battle of the “have nots” in this week’s NFL with the San Francisco 49ers vs. Carolina Panthers spread opening at 3 points in favor of the 49ers 
San Francisco comes into this game with just one win (achieved last week), while the Panthers have zero.
This game should be a yawner unless you’re planning on betting it or are one of the few who believe the 49ers could actually still be good.
Let’s review some important betting trends.
Carolina is 13-3 against the spread versus San Francisco since 1992 (edge: Panthers)
The 49ers are 7-1-3 ATS in their last 11 games following a ATS loss while the Panthers are 1-4 ATS in their last 5 games following a Straight Up loss. San Francisco’s favorable stat is somewhat offset by the fact that they are 1-4 ATS following a Straight Up win. (edge: 49ers)
The 49ers are 1-8-1 ATS in their last 10 games as a road favorite while the Panthers are 7-3 ATS in their last 10 games as an underdog, though they are also 1-5 ATS in their last 6 games as a home underdog of 0.5-3.0. (edge: Panthers)
The Panthers are 9-3 ATS in their last 12 vs. NFC (edge: Panthers)
The Panthers are 2-7 ATS in their last 9 home games vs. a team with a losing road record.
When it comes to the San Francisco 49ers vs. Carolina Panthers spread, the Panthers have a definitive edge of better than 60 percent Gambling911.com believes, but does anyone really want to bet on Carolina these days?
While many of you will be betting the spread in this game, Gambling911.com also suggests considering the UNDER 36 
. In home games, the UNDER has gone 5-15 over the last 3 seasons for Carolina. The UNDER is also 0-7 after two consecutive losses. (edge: UNDER 36) – Dan Shapiro reporting for Gambling911.com.
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