Rams vs. 49ers Betting Preview Thursday Night Football

The Rams vs. 49ers line was shifting between -2.5 and -3 with San Francisco the favorite.  This number appears to be right on the money.

Rams player to watch

QB Matthew Stafford was sensational against the Bills, throwing for 320 yards and two touchdowns. It was the fourth game this season where Stafford was not sacked, and the Rams have won all four with Stafford passing for 12 TDs against two INTs. San Francisco dropped Stafford three times in Week 3, most in any Los Angeles victory this season, but the offensive line in front of him is much more settled than it was in mid-September.
49ers player to watch

WR Jauan Jennings had seven catches for 90 yards and two TDs last week to give him six TDs on the season. Jennings caught just seven TD passes in 45 games in his first three seasons. Jennings had 11 catches for 175 yards and three TDs against the Rams in Week 4. He also had a two-TD day against Los Angeles in Week 18 of the 2021 season.

Key Matchup

Rams WR Cooper Kupp vs. 49ers DB Deommodore Lenoir. Kupp is one of the top receivers out of the slot with his 44 catches from the slot ranking fourth most in the league even though he has missed four games. Lenoir has emerged as one of the better slot defenders but will get one of his toughest tests this week.

Key Injuries

Rams CB Cobie Durant sustained a lung contusion versus the Bills and is out this week. … Rookie C Beaux Limmer is working through a knee injury and is questionable. … The 49ers will be without LT Trent Williams (ankle), S Malik Mustapha and G Ben Bartch (ankle). ... DE Nick Bosa (oblique) is listed as questionable after missing the past three games. ... Niners RB Isaac Guerendo (foot) will be a game-time decision. ... San Francisco LB Dre Greenlaw could make his season debut after tearing his Achilles tendon in the Super Bowl last season.
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