2025 Week 4 Betting Lines

Three blocked field goal attempts in the final two minutes of three early-afternoon games kicked off a crazy Week 3 in the National Football League.

And then we witnessed a menagerie of blocked kicks throughout the day!

It was an exciting week as many outcomes were decided in the last minute of the game.

What will be in store for Week 4. Below are the 2025 Week 4 NFL opening lines, and if there’s a big movement from the look-ahead numbers, that will be notated.

NFL Week 4 spreads are subject to change.

NFL Week 4 Lines

Thursday, September 25, 2025

• Seattle Seahawks at Arizona Cardinals (-1.5)
  • Lookahead line was –2.5

Sunday, September 28, 2025

• Minnesota Vikings (-1.5) at Pittsburgh Steelers
  • Look-ahead line was Steelers -1.

• Washington Commanders (-3) at Atlanta Falcons
  • Look-ahead line was -1.

• New Orleans Saints at Buffalo Bills (-16.5)
  • Look-ahead line was –15.5

• Philadelphia Eagles (-3) at Tampa Bay Buccaneers

• Carolina Panthers at New England Patriots (-4)
  • Look-ahead line was –5.5

• Cleveland Browns at Detroit Lions (-8.5)
  • Look-ahead line was -10.

• Tennessee Titans at Houston Texans (-7)

• Los Angeles Chargers (-6) at New York Giants

• Jacksonville Jaguars at San Francisco 49ers (-3.5)

• Indianapolis Colts at Los Angeles Rams (-4)
  • Look-ahead line was -5.

• Chicago Bears at Las Vegas Raiders (-1.5)
  • Look-ahead line was -2.5.

• Baltimore Ravens (-3) at Kansas City Chiefs

• Green Bay Packers (-6) at Dallas Cowboys
  • Look-ahead line was -5.

Monday, September 29, 2025

• New York Jets at Miami Dolphins (-2.5)

• Cincinnati Bengals at Denver Broncos (-7.5)
  • Look-ahead line was -6.5.