Arizona Cardinals vs. San Francisco 49ers Betting Preview

Written by:
Dan Shapiro
Published on:

The Cardinals vs. 49ers game featured a line of San Francisco -9.5 to -10.5 depending on the book.

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TV: 4:05 p.m. ET, FOX

ABOUT THE CARDINALS (3-6-1): Murray has been efficient with 12 touchdowns against five interceptions and has passed for 2,553 yards and rushed for a club-high 351 and two scores. Veteran wideout Larry Fitzgerald leads the team with 50 receptions for 556 yards despite slowing down while second-year pro Kirk is on the rise after catching six passes for career-highs of 138 yards and three touchdowns in last week's loss to the Tampa Bay Buccaneers. The defense ranks 27th in scoring defense (28.1 points per game) and 31st in total defense (412.5 yards per game) but star pass rusher Chandler Jones is tied for the NFL lead with 11.5 sacks - his fifth straight season of 10 or more.

Arizona has won eight of the last nine games.  San Francisco won the last game a few weeks ago by just three points.

ABOUT THE 49ERS (8-1): Quarterback Jimmy Garoppolo has been solid while throwing for 2,054 yards, 14 touchdowns and eight interceptions but some of his targets are ailing. Star tight end George Kittle (46 receptions, 541 yards) could miss his second straight game with knee and ankle injuries while wideout Emmanuel Sanders (13 for 161, two TDs in three games with the team) will be a game-time decision after suffering a rib injury during Monday's loss. Defensive ends Arik Armstead and Nick Bosa are creating havoc with seven sacks apiece for a stingy unit that ranks second in sacks (35), scoring defense (14.3) and total defense (251.6).

- Dan Shapiro,

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