Indians vs. White Sox Betting Pick, DFS Plays – April 22

Submitted by C Costigan on

Written by :

C Costigan

Published on :

Gambling911.com has your daily fantasy Baseball hot hitters for April 22.

Best Bets – Cleveland -118

Best DFS Picks – Corey Kluber

PITCHING MATCHUP: Indians RH Corey Kluber (0-1, 2.49 ERA) vs. White Sox RH Jeff Samardzija (0-1, 4.29)

Betting Line – Chicago +108, Cleveland -118, Total 7.5

Melky Cabrera (White Sox) – He’s 3-for-7 against Cleveland’s Corey Kluber. 

Jose Abreu (White Sox) – He’s 6-for-17 against Kluber with one home run.

Kluber has allowed just two runs in each of his first three starts.  He is 4-2 career record against the White Sox with one complete game and a 3.09 ERA in 10 games - nine starts.  Aside from Cabrera and Abreu, the Chicago roster is mostly off limits to  daily fantasy players.  Kluber is a decent pick as starting pitcher on the Cleveland side but this will be Samardzija’s first start against the Indians.

Cleveland is 7-3 in the last ten head-to-heads of this series. 

Chicago is 6-13 in their last 19 overall and 3-12 in their last 15 games as an underdog.

The Indians are 20-8 in Kluber’s last 28 starts vs. a team with a losing record and 15-6 in his last 21 starts with 4 days of rest.

- Dan Shapiro, Gambling911.com

Related Content

Baseball in glove

Mariners vs. Rangers Home Run Prop Bets: Dominic Canzone, Joc Pederson, Luke Raley

The Mariners are listed as a -139 favorite, Rangers +114; over/under is 8 runs in this early Monday afternoon game.
Royals vs. Tigers Betting Preview July 24, 2026

Royals vs. Tigers Betting Preview July 24, 2026

The Royals vs. Tigers game Friday evening was seeing close to $1 million in betting volume at some prediction markets, making it among the most wagered on MLB games this day.
<iframe width="560" height="315" src="https://www.youtube.com/embed/j5V5J1tnJJk?si=40gMzeXgFIIsO01y" title="YouTube video player" frameborder="0" allow="accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture; web-share" referrerpolicy="strict-origin-when-cross-origin" allowfullscreen></iframe>

Baseball Betting Solution for Bookies

AcePerHead.com offers a fully managed Pay Per Head (PPH) sportsbook software that allows bookies and agents to offer comprehensive MLB and baseball betting markets, not just cookie cutter money lines and totals you will find with some PPH providers.
Padres vs. Braves Betting Preview July 23, 2026

Padres vs. Braves Betting Preview July 23, 2026

The San Diego Padres play Game 4 of their series in Atlanta against the Braves Thursday. Pay Per Head baseball platforms feature a wide array of team and player prop bets for this game as well.