49ers vs. Cardinals Point Spread: Prediction

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The 49ers vs. Cardinals point spread had Arizona as a +3 home underdog.  Be sure to scroll down for the prediction on this game as well.

The San Francisco 49ers were well on their way to being 2-0 and then Colin Kaepernick decided to throw the game away. Kaepernick threw three interceptions and the San Francisco 49ers lost 28-20. Now the team has an early must-win game at Arizona on Sunday. "This next one is huge. The Cardinals, it counts for two," offensive lineman Alex Boone said, "We need to rebound. We can't slip up. ... This is going to be a big game for us to really show if we can be the team we think we are."

NFL - Sep 21

 

Sep 21

451

SAN DIEGO

+2-115

o45½-110

 
 

1:00 PM

452

BUFFALO

-2-105

u45½-110

 
 

Sep 21

453

DALLAS

-1-110

o44-110

 
 

1:00 PM

454

ST. LOUIS

+1-110

u44-110

 
 

Sep 21

455

WASHINGTON

+6-105

o50½-110

 
 

1:00 PM

456

PHILADELPHIA

-6-115

u50½-110

 
 

Sep 21

457

HOUSTON

PK-110

o41-110

 
 

1:00 PM

458

NY GIANTS

PK-110

u41-110

 
 

Sep 21

459

MINNESOTA

+10-110

o50-110

 
 

1:00 PM

460

NEW ORLEANS

-10-110

u50-110

 
 

Sep 21

461

TENNESSEE

+7-110

o42½-110

 
 

1:00 PM

462

CINCINNATI

-7-110

u42½-110

 
 

Sep 21

463

BALTIMORE

-1-115

o41½-110

 
 

1:00 PM

464

CLEVELAND

+1-105

u41½-110

 
 

Sep 21

465

GREEN BAY

+2½-110

o52½-110

 
 

1:00 PM

466

DETROIT

-2½-110

u52½-110

 
 

Sep 21

467

INDIANAPOLIS

-7-110

o45-110

 
 

1:00 PM

468

JACKSONVILLE

+7-110

u45-110

 
 

Sep 21

469

OAKLAND

+14-105

o46½-110

 
 

1:00 PM

470

NEW ENGLAND

-14-115

u46½-110

 
 

Sep 21

471

SAN FRANCISCO

-3-105

o41½-110

 
 

4:05 PM

472

ARIZONA

+3-115

u41½-110

 
 

Sep 21

473

DENVER

+4½-115

o48½-110

 
 

4:25 PM

474

SEATTLE

-4½-105

u48½-110

 
 

Sep 21

475

KANSAS CITY

+4-115

o42-110

 
 

4:25 PM

476

MIAMI

-4-105

u42-110

 
 

Sep 21

477

PITTSBURGH

+3-125

o41½-110

 
 

8:30 PM

478

CAROLINA

-3+105

u41½-110

 

NFL - Sep 22

 

Sep 22

479

CHICAGO

+2½EV

o45½-110

+130

 

8:35 PM

480

NY JETS

-2½-120

u45½-110

-150

 

- Don Shapiro, Gambling911.com  

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