2025 MLB Opening Day Lines Now Up

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The real opening day of MLB starts on Thursday. Only Colorado and Tampa play their first game on Friday.

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All the opening day pitching matchups have been announced and now the oddsmakers at SportsBetting.ag have opening day lines.

  • The Friday game has the biggest underdog in Colorado at Tampa Bay
  • The biggest favorite on Thursday is Seattle and Logan Gilbert over the A’s.
  • The home team is the favorite in nine games, the road team is the favorite in five games.
  • There is one pick’em, Minnesota at STL.

Milwaukee Brewers                   +142

F Peralta

New York Yankees                       -155

C Rodon

 

Baltimore Orioles                       -119

Z Eflin

Toronto Blue Jays                     +109

J Berrios

 

Boston Red Sox                         +102

G Crochet

Texas Rangers                            -112

N Eovaldi

 

Philadelphia Phillies                  -168

Z Wheeler

Washington Nationals               +144

M Gore

 

Cleveland Guardians                 +122

T Bibee

Kansas City Royals                   -133

C Ragans

 

New York Mets                            +115

C Holmes

Houston Astros

F Valdez                                       -125

 

San Francisco Giants                +105

L Webb

Cincinnati Reds                          -115

H Greene

 

Atlanta Braves                            -132

C Sale

San Diego Padres                      +121

M King

 

Los Angeles Angels                   -152

Y Kikuchi

Chicago White Sox                    +139

S Burke

 

Pittsburgh Pirates                      -158

P Skenes

Miami Marlins                             +134

S Alcantara

 

Minnesota Twins                        -105

P Lopez

St. Louis Cardinals                    -105

S Gray

 

Detroit Tigers                              +134

T Skubal

Los Angeles Dodgers                -146

B Snell

 

Athletics                                      +155

L Severino

Seattle Mariners                         -169

L Gilbert

 

Chicago Cubs                             +135

J Steele

Arizona Diamondbacks             -147

Z Gallen

             

Colorado Rockies                      +160

K Freeland

Tampa Bay Rays                        -190

R Pepiot

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