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The 2018 NFL Week 1 sportsbook odds appear below and were as of Tuesday September 4. For updated lines go here
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2018 Week 1 NFL Odds
Atlanta Falcons at Philadelphia Eagles (-2.5, 45)
Pittsburgh Steelers at Cleveland Browns (+4, 45.5)
San Francisco 49ers at Minnesota Vikings (-6, 46)
Buffalo Bills at Baltimore Ravens (-7, 40.5)
Jacksonville Jaguars at New York Giants (+3, 43.5)
Tampa Bay Buccaneers at New Orleans Saints (-9.5, 49.5)
Houston Texans at New England Patriots (-6, 51)
Cincinnati Bengals at Indianapolis Colts (-3, 47)
Tennessee Titans at Miami Dolphins (+1.5, 45)
Kansas City Chiefs at Los Angeles Chargers (-3.5, 47.5)
Seattle Seahawks at Denver Broncos (-3, 42)
Dallas Cowboys at Carolina Panthers (-3, 42.5)
Washington Redskins at Arizona Cardinals (PK, 44)
Chicago Bears at Green Bay Packers (-7.5, 47.5)
New York Jets at Detroit Lions (-6.5, 44.5)
Los Angeles Rams at Oakland Raiders (+4.5, 49.5)
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Before You Bet
Sportsbook odds are often subject to fluctuate wildly as key player injuries and suspensions come to light. Always monitor the live odds here
The Ravens lose Jimmy Smith, arguably their top cornerback. This has resulted in poor play in the past. Baltimore hosts the Bills as a -7 favorite. You wouldn't know it from the line though, which has not dropped below 7 after moving up from -4 over the months.
The Panthers lose one of their top linebackers, Thomas Davis. He is suspended four games for violating league's policy on performance-enhancing drugs.
Colts running back Robert Turbin is out for violating league's policy on using performance-enhancing drugs. This hurts as Indianapolis is lacking depth at this position.
Dante Fowler Jr. is out for the Jaguars.
"Fowler isn't a starter, but he is a key part of the rotation and lines up opposite Yannick Ngakoue in the third-down rush package. With second-year player Dawuane Smoot battling an ankle injury (after missing time earlier in camp because of a hand injury), the Jaguars are going to have to rely on Lerentee McCray and rookie first-round pick Taven Bryan to back up Calais Campbell. Fowler had eight sacks last season and is solid against the run. That's probably where his loss will be felt the most in the opener against the New York Giants and running back Saquon Barkley." -- Michael DiRocco, ESPN.com
Julian Edelman is out for the Patriots. There isn't one receiver who can step into Edelman's role, so the Patriots will lean on multiple receivers.
Other key injuries include Mark Ingram of the Saints and Nigel Bradham of the Eagles.
- Don Shapiro, Gambling911.com
