San Francisco 49ers vs. New England Patriots Week 7 Betting Odds, Prop Bets

Quarterback Jimmy Garoppolo's current and former employers go head-to-head for the first time since their headlines-grabbing trade in 2017 when the San Francisco 49ers visit the New England Patriots on Sunday afternoon.

The 14th all-time meeting between the reigning NFC West and AFC East champs pits franchises that have combined for 11 Super Bowl crowns, yet have never met in the postseason.

In fact, the 49ers (five titles) and Patriots (six) haven't squared off at all since a 30-17 New England road win in 2016 in a game in which Tom Brady celebrated a rare San Francisco Bay Area homecoming with four touchdown passes.

Expectations were high once again for both teams this season, but neither has come close to meeting them so far, with quarterback play having been a focal point of the issues.

The 49ers (3-3) rode one of Garoppolo's career-best efforts to a 24-16 home win over the Los Angeles Rams on Sunday night.

The 23-for-33, 268-yard, three-touchdown effort, however, came on the heels of one of his career-worst outings, when he was pulled at halftime of a 43-17 home loss to Miami, having gone just 7-for-17 for 77 yards with two interceptions.

49ers coach Kyle Shanahan cited his quarterback's health -- Garoppolo had sat out the previous two games with a high ankle sprain -- as a contributing factor to the benching, before praising his signal-caller for the bounce-back effort against the Rams.

"You learn more about each other through all the experiences you go through," Shanahan said this week about his relationship with Garoppolo. "He played a hell of a game (against the Rams). I know he's pumped to go back to New England. I haven't been there for a while, either, and looking forward to watching him there."

Garoppolo is 21-7 as the 49ers' starting quarterback since being acquired on Halloween nearly three years ago for a second-round draft pick. The Eastern Illinois product played his first 3 1/2 seasons with the Patriots, for whom he made just two starts, winning them both in Brady's absence in 2016.

For the first time since 2000, the Patriots (2-3) don't have either Brady or Garoppolo on the roster. They also have a losing record five or more games into a season for the first time since 2001.

Newcomer Cam Newton got the perennial AFC power off to a good start with two wins and a 29.0-point scoring average in the first three games. But he has since tested positive for the coronavirus, which caused him to sit out a 26-10 loss to Kansas City before struggling through a 17-for-25, 157-yard, two-interception debacle in last week's 18-12 home defeat at the hands of Denver.

Patriots coach Bill Belichick noted this week that he's more interested in how his quarterback does Sunday than his ex-quarterback.

"I'm glad that it's worked out for him in San Francisco," he said of Garoppolo. "I hope it doesn't work out on Sunday."

Belichick hopes to get more from star slot receiver Julian Edelman this week after a knee injury has limited him to a total of seven catches in the past three games.

Edelman has practiced this week, which is more than the 49ers' top running back, Raheem Mostert, can say. He likely will be out with a sprained ankle sustained in the Rams game.

On a positive note, both teams are coming off impressive defensive efforts.

One week after getting scorched by the Dolphins for 436 total yards, including 342 through the air, the 49ers limited Jared Goff to 198 passing yards and the Rams to a total of 311 yards.

Meanwhile, the Patriots were even better defensively against Denver, holding the Broncos to 299 total yards.

The Patriots put starting right tackle Jermaine Eluemunor on injured reserve Wednesday. Mike Onwenu is expected to get the start.

49ers' defensive starters safety Jaquiski Tartt (groin) and Kwon Alexander (ankle) did not practice Wednesday.

--Field Level Media

49ers @ Patriots Sun, Oct 25, 2020 EST

Rot	First To Score	Moneyline
1001	49ers	-110
1002	Patriots	-120

Rot	Score in 1st 6½ min	Moneyline
1003	Yes	-110
1004	No	-120

Rot	First Score of the Game	Moneyline
1005	TD	-155
1006	Any Other Score	+125

Rot	First Scoring Play	Moneyline
1007	49ers TD	+180
1008	49ers FG	+350
1009	49ers Any Other Score	+5000
1010	Patriots TD	+160
1011	Patriots FG	+350
1012	Patriots Any Other Score	+5000

Rot	Will there be a Defensive or Special Teams TD	Moneyline
1013	Yes	+200
1014	No	-250

Rot	Total TDs in the Game	Moneyline
1015	Over  5½  TDs	+130
1016	Under  5½  TDs	-160

Rot	Total FGs Scored in the Game	Moneyline
1017	Over  3½  FGs	+130
1018	Under  3½  FGs	-160

Rot	Longest TD in the Game	Moneyline
1019	Over  38½  Yards	-115
1020	Under  38½  Yards	-115

Rot	Shortest TD in the Game	Moneyline
1021	Over  1½  Yards	-110
1022	Under  1½  Yards	-120

Rot	A Team to Score 3 Unanswered Times	Moneyline
1025	Yes	-200
1026	No	+165

Rot	Team To Score Longest TD	Moneyline
1027	49ers	Ev
1028	Patriots	-130

Rot	Team To Score Longest FG	Moneyline
1029	49ers	-110
1030	Patriots	-120

Rot	Team Scoring 1st Wins Game	Moneyline
1031	Yes	-165
1032	No	+135

Rot	Team to Call 1st Timeout	Moneyline
1033	49ers	-115
1034	Patriots	-115

Rot	Race To 10 Points	Moneyline
1044	49ers	-105
1045	Patriots	-155
1046	Neither	+6000

Rot	Will the Game go to Overtime	Moneyline
1047	Yes	+800
1048	No	-1800

Rot	Highest Scoring Quarter	Moneyline
1052	1st Quarter	+450
1053	2nd Quarter	+180
1054	3rd Quarter	+450
1055	4th Quarter	+200
1056	Tie	+700

Rot	Winning Margin	Moneyline
1057	49ers to win by 1-3 pts	+650
1058	49ers to win by 4-6 pts	+900
1059	49ers to win by 7-10 pts	+750
1060	49ers to win by 11-13 pts	+1700
1061	49ers to win by 14-17 pts	+1200
1062	49ers to win by 18-21 pts	+1700
1063	49ers to win by 22 or more pts	+900
1064	Patriots to win by 1-3 pts	+600
1065	Patriots to win by 4-6 pts	+850
1066	Patriots to win by 7-10 pts	+625
1067	Patriots to win by 11-13 pts	+1400
1068	Patriots to win by 14-17 pts	+950
1069	Patriots to win by 18-21 pts	+1350
1070	Patriots to win by 22 or more pts	+675

Rot	Total Points Scored	Moneyline
1071	00-14 Points	+3000
1072	15-21 Points	+1300
1073	22-28 Points	+600
1074	29-35 Points	+375
1075	36-42 Points	+325
1076	43-49 Points	+350
1077	50-56 Points	+450
1078	57-63 Points	+675
1079	64-70 Points	+1150
1080	71-77 Points	+2200
1081	78 or More Points	+2700

Rot	1st Half Total TDs Scored	Moneyline
1082	Over  2½  TDs	-115
1083	Under  2½  TDs	-115

Rot	1st Half Total FGs Scored	Moneyline
1084	Over  1½  FGs	+125
1085	Under  1½  FGs	-155

Rot	Score in Last 2 min of the 1st Half	Moneyline
1086	Yes	-260
1087	No	+210